• To run a highly efficient process for gene-to-structure, allowing the determination of approximately 30 novel structures per year.
• To establish a collaborative network, and processes, to strengthen structural biology research in Sweden in particular, and related biomedical research in general.
• To build on the knowledge generated internally in order to establish chemical biology as a means to dissect and investigate novel biological pathways.

Biology Areas

Two Structural Biochemistry teams (PI:s Pär Nordlund and Herwig Schüler) pursue individual biology programs. The teams provide the scientific driving forces to the project and are responbible for structural milestones. The Swedish funders have nominated a reference group of Swedish researchers to aid SGC Stockholm identify protein target areas. Examples of biology areas are given below. For complete listings visit the homepages of the individual teams.

• Nucleotide metabolism (Nordlund)
• Domains in Apoptosis and Receptor Signaling (Nordlund)
• Phosphoinositide and Lipid Signaling (Nordlund/Schüler)
• PARPs (Schüler)
• Amino Acid metabolism (Schüler)
• ATPases [Hsp70, RNA helicases, AAA] (Schüler)

The Biotechnology unit maintains a state-of-the-art high throughput process for protein production and crystallisation.

Core Scientists provide senior expertise within their specific areas and maintain vital infrastructure.

    * Biophysics (Natalia Markova)
    * X-ray Crystallography (Martin Moche)
    * Research Informatics (Per Kraulis)