Structural Genomics Consortium

SGC Stockholm has been wound down as of July 1 2011.

Please visit:

Structural and chemical biology to explore epigenetic signalling (follow on project)

SGC Stockholm Structure Gallery

SGC Stockholm Publications

thesgc.org (international site)



High resolution poster for download (pdf)

The SGC infrastructure for high-throughput protein production and protein crystallography is now available to external users in the form of a Protein Science Facility affiliated to Science for Life Laboratory.

Links to information on SGC science programs and follow-on projects are found below.

• Structural and chemical biology to explore epigenetic signalling
• SGC Biology 1 (Nordlund), not updated
• SGC Biology 3 (Schüler), not updated

The Structural Genomics Consortium (SGC) is a not-for-profit organization that aims to determine the three dimensional structures of proteins of medical relevance, and place them in the public domain without restriction. The SGC operates out of the Universities of Oxford and  Toronto and Karolinska Institutet, Stockholm. During the first phase of the project, more than 450 protein structures were deposited in the PDB. The goal of 660 additional structures in the second funding phase (July 1 2007 - June 30 2011) will be reached early spring 2011.  SGC works on a Target List of ~2,400 proteins with relevance to human health comprising proteins associated with diabetes, cancer, genetic and epigenetic disease as well as with infectious diseases such as malaria.

SGC Stockholm

The Stockholm laboratory was established in 2005 after funding had been provided by the Swedish Foundation for Strategic Research (SSF), the Knut and Alice Wallenberg foundation (KAW), the Swedish Governmental Agency for Innovation Systems (VINNOVA) and Karolinska Institutet. The laboratory is hosted by the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. Currently the activities of SGC Stockholm are being wound down, in the absence of continued funding support beyond June 30, 2011.

Structural Genomics and Impact for Society

SGC deposited its 1000th official structure into the Protein Data Bank in July 2010. The vast amount of structural information generated by the SGC is expected to have a tremendous impact on human health by furthering our understanding of relevant proteins - leading to new hypotheses and new directions for biomedicinal research - and by supplying new targets for therapeutic intervention. It will also provide the structural framework for the rational design of new or improved drugs that can inhibit or enhance protein function. The significant contributions of structural biology to drug discovery are well documented (e.g. http://publications.nigms.nih.gov/structlife/chapter4.html).